Groton Biosystems and New England Controls (NEC), a local business partner for Emerson Process Management, have partnered to provide a complete solution for automated data collection, data reporting, and feedback control for all types of bioreactors and fermentors. The pairing of NEC’s expertise in a wide array of process automation and information management solutions and the ARS-M automated sampling systems will revolutionize standard operating procedures in the lab.

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Automated Reactor Sampling (ARS) Systems

Link to NEC Web Site

Groton Biosystems supplies a multiplexed Automated Reactor Sampling (ARS™) System for the Agilent 1200 and 1100 Series LC System for online HPLC assays. The two companies have collaborated to create a closed-loop solution for monitoring cell culture and fermentation near real time in biotech and pharmaceutical systems. The Agilent 1200 and 1100 Series LC System and the Groton Biosystems ARS help ensure proper feeding of reactors and fermentors, optimizes product yield, and enables companies to follow the FDA's PAT Initiative.

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Automated Reactor Sampling (ARS) Systems

Link to Agilent Web Site

Groton Biosystems and DasGip have entered into a collaboration to provide biopharmaceutical and biofuel customers with a total "closed loop" solution for online process monitoring and feed back control. DASGIP AG develops and manufactures technologically-superior parallel bioreactor systems designed for the lab-scale cultivation of bacterial, mammalian and human cells. The collaboration provides automated near real time online monitoring for lab-scale and process development labs. This solution also enables process monitoring via HPLC, nutrient monitors, and cell counters. The ability to continuously sample, analyze and properly feed the reactors and fermentation process will increase the efficiency and productivity of the entire process. The closed loop solution is in alignment with the FDA’s PAT initiative.

GROTON/DASGIP/YSI - Automated On-Line Real Time Reactor Feedback Control

Automated Reactor Sampling (ARS) Systems

Link to DASGIP Web Site

Groton Biosystems is a Value Added Reseller of the YSI 7100 Bioanalytical System and the YSI 2700 Monitoring Analyzer.

YSI Life Sciences and Groton Biosystems work together to offer the cell culture and fermentation scientist innovative combinations of YSI analyzers and Groton Biosystems Automated Reactor Sampling (ARS) Systems to provide around-the-clock online sampling and measurement for process development and production environments. The 2700 ARS and 7100 ARS improve process knowledge while making more productive use of time. Integrate up to eight bioreactors in an online analytic system which provides sanitary sampling and automated cleaning. Sampling intervals and analytic parameters are user-programmable for each reactor. Analytes measured include up to 2 of the following for the 2700 ARS (Glucose, L-Lactate, L-Glutamate, L-Glutamine, Sucrose, Ethanol, Methanol, Lactose, Galactose, Choline, or Hydrogen peroxide) and up to 6 of the following for the 7100 ARS (Glucose, L-Lactate, L-Glutamate, L-Glutamine, Ammonium, Potassium, Ethanol, Sucrose, Galactose or Methanol).

The ARS system can interface to a variety of bioreactors, fermentors, and other process liquids.

Automated Reactor Sampling (ARS) Systems

Around-the-Clock Nutrient Monitoring

Link to YSI Web Site

Groton Biosystems is a Value Added Reseller of the Shimadzu HPLC System.

Groton Biosystems and Shimadzu have partnered to enhance ethanol monitoring systems. The collaboration is focusing on the interface of the ARS series online sampling monitors with Shimadzu's Prominence HPLC (high performance liquid chromatograph) to form a closed-loop solution for online analysis. Manufacturers will be able to quickly and efficiently optimize enzyme levels in mash by incorporating this system into the bio-ethanol production process. With this automated HPLC ethanol monitoring system, manufacturers can determine the appropriate times to add enzymes with only a few key strokes. Optimized enzymes yield more product and limit the formation of useless by-products. This system will function in the high-solids/high-viscosity environment found in both corn and biomass fermentations.

Automated Reactor Sampling (ARS) Systems

Link to Shimadzu Web Site

and ELECTRIC POWER RESEARCH INSTITUTE (EPRI)

Groton Technology, Radiological Solutions (RSI), and Electric Power Research Institute (EPRI) are collaborating to develop online monitoring systems for nuclear reactor cooling water.  This technology will provide a direct, online system for monitoring water chemistry in nuclear plant streams in order to detect early indicators of system contamination and corrosion.

Link to EPRI Web Site

Link to RSI Web Site