ARS ON-LINE SAMPLING SYSTEMS

Implementing an Automated Reactor Sampling System for Monitoring Cell Culture Bioreactors Acrobat PDF
Genentech, Inc. - Process Development Engineering. Monitoring of cell culture bioreactors is critical to process control and optimization. Currently offline sampling is used in various cell culture operations. This process is time consuming and labor intensive. Automating the sampling process is highly desired but concerns about sterility, sample volume and cross contamination are common. This paper presents the evaluation of an automated sampling system by Groton Biosystems.

On-line Amino Acid Analysis from a Small Scale CHO Cell Bioreactor Acrobat PDF
Biogen Idec - This Application Note describes a fast, accurate and reproducible measurement of 21 amino acids in a Chinese Hamster Ovary (CHO) cell culture using an online HPLC instrument. The hyphenated system combines the automatic sampling and reactor sterility protection of the Groton ARS with a high performance amino acid separation system provided by the Agilent 1100 Series HPLC System. The set-up, which is described in this Application Note, was used for in-process analysis during the course of a 14-day bioreactor run, which has been previously demonstrated using pulsed amperomeric detection. This tool provides immediate sampling and testing of a bioreactor that does not compromise bioreactor or samples, reduces hands on work and improves in-process monitoring of a bioreactor.

Analysis of Native Proteins in Free Capillary Zone Electrophoresis Acrobat PDF

Analysis of Sulfonic Acids in Waste Water Acrobat PDF

Baby Formula Analysis by CE Acrobat PDF

Carbohydrates in Chocolate Extract by CE Acrobat PDF

Comparison of Anions in a Regular and Diet Cola using Conductivity Detection Acrobat PDF

Determination of Ammonium Content in Saliva Using Conductivity Detection Acrobat PDF

Determination of Organic Acids in Red Wine Acrobat PDF

Diet Cola Analysis by CE Acrobat PDF

Impurities in Insulin by CE Acrobat PDF

Peak Purity Determination using Diode Array Detection Acrobat PDF

Trace Chloride and Sulfate in Glacial Acetic Acid using Conductivity Detection Acrobat PDF