| ARS-M Series Interface Options |
| Sample Collector |
The ARS-M delivers samples to sterile vials in a sample collector for post run analysis. Using Peltier temperature control, the chilled sample collector maintains temperature in a range of 4°C to 37°C. Vial trays available in 24, 60 and 96 positions. Sub-zero Sample Collector also available. |
| Nutrient Monitors |
The ARS-M supports nutrient monitors from several vendors that can provide analysis for glucose, lactate, glutamate, glutamine, sucrose, ammonium, potassium, ethanol, lactose, methanol, and chlorine. |
| HPLC Systems |
HPLC is one of the most widely used analytical tools in the biotech industry. The ARS-M can deliver sample to any HPLC system that supports a simple digital interface. Dependent on the operation, the ARS-M can function as the master controller or as a slave to the HPLC. |
| Cell Counters |
The ARS-M
interfaces to industry-standard cell counters, including the
Beckman ViCELL XR and the Innovatis Cedex RC. The ARS-M
provides a sterile and automatic connection between the bioreactor
sample and the cell counter and ensures rapid delivery of samples for
accurate online cell counts.
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| Minimum Sample Dead Volume (Typical) |
| Process Development |
1/16" system (0.040 id.) 1.4 ml plus volume of connection to reactor |
| Pilot Plant/Production |
1/4" system 40 ml plus volume of connection to reactor
1/2" system 160 ml plus volume of connection to reactor |
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| Sample Wetted Surfaces |
| Process Development |
PEEK or 316 SS bodies with PTFE, Chemraz or EPDM valve diaphragms |
| Pilot Plant/Production |
316 SS body, polishes from 11–38µin, plastic bonnet and PTFE or EPDM diaphragms |
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| Sample Tubing Specification |
| Process Development |
1/16" o.d. PEEK or 316 SS |
| Pilot Plant/Production |
316 SS – dimensions to order |
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| Reactor Connection |
| Process Development |
A Groton Biosystems Reactor Interface Module to in-situ probe connecting to 1/16" o.d. tubing |
| Pilot Plant/Production |
Tri-clamp Reactor Interface Pneumatic Valve dimensioned to order. Flex or permanent mountings |
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| Valve Actuators |
| Process Development |
Electric – controlled by ARS-M |
| Pilot Plant/Production |
Pneumatic (90 psi compressed air site supplied) air solenoid controlled by ARS-M |
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| Valve Control |
| Process Development |
By ARS-M Control System |
| Pilot Plant/Production |
Main reactor valve by Reactor Control System
All other valves by ARS-M Control System Optional – All valves controlled by ARS-M |
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| Cleaning Systems (CIP) |
| |
Fully automated for development and production models.
Cleaning chemistry to conform to customer specification.
Sodium hydroxide, hypochlorite, or standard detergents compatible
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Sterilization Systems
Fully automated for development and production models |
| Process Development |
Chemical sterilization systems utilize ethanol, formalin, or hypochlorite |
| Pilot Plant/Production |
Large scale production ARS systems (1/2"+) support SIP (steam site supplied.) |
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| Reagent Consumption per Sterilization Cycle for Chemical Sterilization Processes (Typical) |
| Process Development |
15 ml |
| Pilot Plant/Production |
100 ml |
| |
| Reagent Consumption per Cleaning Cycle (Typical) |
| CLEANING REAGENT |
RINSE/NEUTRALIZATION REAGENT |
| Process Development |
5 ml |
Process Development |
100 ml |
| Pilot Plant/Production |
150 ml |
Pilot Plant/Production |
900 ml |
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| Control System |
| Development/Production |
ARS-M Control System
(Upgrades of ARS-M Control System to GPA fraction collection and/or other assay systems available.) |
